Functional Interrogation of Enhancer Connectome Prioritizes Candidate Target Genes at Ovarian Cancer Susceptibility Loci

Identifying causal regulatory variants and their target genes from the majority of non-coding disease-associated genetic loci is the main challenge in post-Genome-Wide Association Studies (GWAS) functional studies.Although chromosome conformation capture (3C) and its derivative technologies have been successfully applied to nominate putative causal

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Design Optimization of Long-Span Cold-Formed Steel Portal Frames Accounting for Effect of Knee Brace Joint Configuration

The application of cold-formed steel channel sections for portal frames becomes more popular for industrial and residential purposes.Experimental tests RAW CACAO BUTTER showed that such structures with long-span up to 20 m can be achieved when knee brace joints are included.In this paper, the influence of knee brace configuration on the optimum des

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